Investigation of genetic factors associated with polycystic ovary syndrome
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Abstract:
Introduction: Polycystic ovary syndrome (PCOS) is one of the most common endocrine disorders and causes 75% of infertility due to ovulation disorders in reproductive age. Women with PCOS have oligomenorrhea and hyperandrogenism that affect their quality of life and fertility at the same time. This syndrome has been one of the most controversial endocrine issues for many years. Research today suggests that PCOS is an inherited disease and that genes are involved in transmission to the next generation. The results of this study, which was performed on thousands of women around the world, show that the expression of some genes has changed. The genes that have been studied are responsible for the synthesis and regulation of steroid hormones, the regulation of gonadotropins, and the synthesis and function of insulin. Although the underlying cause of pathogenesis is not yet known, there is evidence for the role of genetic factors, lifestyle, nutrition, and environmental pollution in the development of the disease. Therefore, it is hoped that the treatment of this heterogeneous syndrome will improve with the help of personalized medicine. Further studies are needed to determine the association between the various factors that may play an active pathogenic role in PCOS.
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Journal title
volume 24 issue 2
pages 276- 282
publication date 2022-04
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